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Table 2 Comparison of the greenness profiles of proposed and a reported method using ESA tool

From: Development of an eco-friendly HPLC method for the stability indicating assay of binary mixture of ibuprofen and phenylephrine

Reagents and instruments

Proposed method

Reported method [17]

Chloroform

0

2

Methanol

0

6

Ammonia

0

2

0.1%hexanesulfonic acid

0

0

Acetonitrile

6

0

Waste

3

3

Occupational hazards

3

3

Total penalty points

12

16

Total score

88

84