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Table 2 The SI of compound 11b

From: Discovery of novel 2,3,4,5-tetrahydrospiro[benzo[c]azepine-1,1’-cyclohexan]-5-ol derivatives as PARP-1 inhibitors

Compounds

SI [f]

HPAEpiC [g]

IOSE80 [h]

HIEC [i]

HTB-125 [j]

11b

15.38 ± 0.97

10.57 ± 2.01

6.12 ± 1.76

7.06 ± 1.32

Rucaparib

8.32 ± 1.43

11.86 ± 1.88

3.98 ± 0.89

4.32 ± 1.51

  1. [f] SI = CC50/IC50; Values are presented as means ± SD of at least three independent determinations; [g] Human normal alveolar epithelial cells; [h] Human normal ovarian epithelial cells; [i] Human normal intestinal epithelial cells; [j] Human normal breast cell
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BMC Chemistry

ISSN: 2661-801X

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