Skip to main content

Table 3 In vitro inhibitory activity of compound 11b against PARP-1/2.

From: Discovery of novel 2,3,4,5-tetrahydrospiro[benzo[c]azepine-1,1’-cyclohexan]-5-ol derivatives as PARP-1 inhibitors

Compounds

IC50[a] (nM)

PARP-1

PARP-2

11b

19.24 ± 1.63

32.58 ± 1.97

Rucaparib

23.88 ± 2.90

25.79 ± 3.17

  1. [a] IC50 values reported as an average ≥ 3 determinations with standard deviation (SD) reported (IC50 = Mean ± SD)
Back to article page

BMC Chemistry

ISSN: 2661-801X

Contact us