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Table 4 Pharmacokinetic prediction of compound 11b

From: Discovery of novel 2,3,4,5-tetrahydrospiro[benzo[c]azepine-1,1’-cyclohexan]-5-ol derivatives as PARP-1 inhibitors

Compound

Water solubility [k]

Plasma protein binding [l]

Acute oral toxicity [m]

Tetrahymena pyriformis [n]

Bioavailability Score

11b

-3.606

0.781

2.752

1.979

0.55

Rucaparib

-3.088

0.643

2.673

1.429

0.55

  1. [k] Unit: logS; [l] Unit: 100%; [m] Unit: log(1/(mol/kg)); [n] Unit: pIGC50 (µg/L)
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BMC Chemistry

ISSN: 2661-801X

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