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Table 1 Cytotoxic evaluation (IC50, µM) of compounds 4–9, as compared to staurosporine, against human liver carcinoma HepG2 cells and WI 38 normal cells

From: Novel 8-Methoxycoumarin-3-Carboxamides with potent anticancer activity against liver cancer via targeting caspase-3/7 and β-tubulin polymerization

Comp No

IC50 value (µM)

HepG2

WI 38

4

17.2 ± 1.05

NT*

5

0.9 ± 0.05

24.1 ± 1.46

6

23.6 ± 1.43

NT*

7

2.57 ± 0.16

NT*

8

5.18 ± 0.31

NT*

9

41.6 ± 2.52

NT*

STU

8.4 ± 0.51

26.7 ± 1.62

  1. *NTnot tested. The data provided represents the average value with its standard deviation of the mean (SEM), obtained from at least three separate experiments
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BMC Chemistry

ISSN: 2661-801X

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