Solubility of mesalazine in pseudo-binary mixtures of choline chloride/ethylene glycol deep eutectic solvent and water at 293.15 K to 313.15 K

Table 10 Apparent thermodynamic parameters for 5-ASA dissolution behavior in ChCl/EG DES (1:2 molar ratio) + water mixtures at the harmonic temperature (303.0 K).

w₂ ^a	Δ_solG^◦ (kJ mol⁻¹)	Δ_solH^◦ (kJ mol⁻¹)	Δ_solS^◦ (J mol⁻¹ K⁻¹)	TΔ_solS^◦ (kJ mol⁻¹)	ζ_H^sol	ζ_TS^sol
0.00	12.72	22.60	32.59	9.87	0.696	0.304
0.10	12.41	19.59	23.70	7.18	0.732	0.268
0.20	12.04	20.73	28.69	8.69	0.705	0.295
0.30	11.57	23.50	39.37	11.93	0.663	0.337
0.40	11.04	24.00	42.78	12.96	0.649	0.351
0.50	10.60	23.62	42.99	13.03	0.645	0.355
0.60	10.20	21.97	38.83	11.77	0.651	0.349
0.70	9.84	19.79	32.86	9.96	0.665	0.335
0.80	9.45	16.85	24.43	7.40	0.695	0.305
0.90	8.99	14.58	18.44	5.59	0.723	0.277
1.00	8.51	11.09	8.52	2.58	0.811	0.189

The combined expanded uncertainties U are U_c(\(\Delta_{sol} H^{ \circ }\)) = 0.06 \(\Delta_{sol} H^{ \circ }\); Uc(\(\Delta_{sol} G^{ \circ }\)) = 0.06 \(\Delta_{sol} G^{ \circ }\) and Uc(\(\Delta_{sol} S^{ \circ }\)) = 0.06 \(\Delta_{sol} S^{ \circ }\)(0.95 level of confidence)
^a w₂ is mass fraction of ChCl/EG DES in ChCl/EG DES + water mixtures in the absence of 5-ASA

ISSN: 2661-801X