BMC Chemistry

Table 6 Larvicidal profiles of compounds 1(a–f), 2(a–e) on Culex sp. second-instar larvae

From: Cu (II)-catalyzed: synthesis of imidazole derivatives and evaluating their larvicidal, antimicrobial activities with DFT and molecular docking studies

Compound	Mortality (%)^a				LD₅₀ (μg/mL)
	Concentration (μg/mL)
	10	25	50	100
1a	15.2 ± 0.31	53.1 ± 0.31	80.2 ± 0.34	91.3 ± 0.34	34.9
1b	12.3 ± 0.39	22.3 ± 0.39	79.5 ± 0.34	82.3 ± 0.34	47.3
1c	19.2 ± 0.31	35.2 ± 0.31	76.2 ± 0.34	90.3 ± 0.34	39.6
1d	12.3 ± 0.39	22.3 ± 0.39	79.5 ± 0.34	82.3 ± 0.34	47.3
1e	15.2 ± 0.31	25.2 ± 0.31	86.2 ± 0.34	92.3 ± 0.34	40.9
1f	12.3 ± 0.39	32.3 ± 0.39	79.5 ± 0.34	82.3 ± 0.34	44.1
2a	15.2 ± 0.31	35.2 ± 0.31	88.2 ± 0.34	95.3 ± 0.34	36.7
2b	12.3 ± 0.39	42.3 ± 0.39	79.5 ± 0.34	82.3 ± 0.34	40.5
2c	–	–	15.2 ± 0.31	25.2 ± 0.31	< 100
2d	12.3 ± 0.39	22.3 ± 0.39	79.5 ± 0.34	82.3 ± 0.34	47.3
2e	15.2 ± 0.31	35.2 ± 0.31	86.2 ± 0.34	92.3 ± 0.34	37.7
DMSO	–	–	–	–	–
Permethrin	11.1 ± 0.19	51.1 ± 0.19	76.3 ± 0.14	100 ± 0.0	35.4

(–) nil active,The values represented the three-replicate ± SD

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