BMC Chemistry

Table 1 Optimization of the reaction conditions

From: Efficient synthesis of 3-alkyl-2-(-1H-1,2,3-triazolyl)methyl)thio)-2,3-dihydroquinazolin-4(1H)-one derivative via multistep synthesis approach by novel Cu@Py-Oxa@SPION catalyst

Entry	Catalyst	Amount (mg)	Solvent	Isolated yield (%)
1	No catalyst	0	EtOH	0
2	Cu@Py-Oxa@SPION	20	EtOH	17
3	Cu@Py-Oxa@SPION	40	EtOH	50
4	Cu@Py-Oxa@SPION	50	EtOH	86
5	Cu@Py-Oxa@SPION	70	EtOH	86
6	Cu@Py-Oxa@SPION	50	H₂O	0
7	Cu@Py-Oxa@SPION	50	CH₂Cl₂	36
8	Cu@Py-Oxa@SPION	50	DMF	24
9	Cu@Py-Oxa@SPION	50	MeOH	62
10	Py-Oxa@SPION	50	EtOH	0
11	CuI	50	EtOH	51
12	Cu@Py-Oxa@SPION^a	50	EtOH	86

Reaction conditions: 3-benzyl-2-(prop-2-yn-1-ylthio)quinazolin-4(3H)-one (1 mmol), N-benzyl-2-chloroacetamide (1 mmol), NaN₃ (1.2 mmol),solvent (5 mL), r.t, 24 h
^aThe reaction was performed under reflux conditions

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ISSN: 2661-801X

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