BMC Chemistry

Table 2 Scope and generality of Cu@Py-Oxa@SPION catalyzed synthesis of 3-alkyl-2-(-1H-1,2,3-triazolyl)methyl)thio)-2,3-dihydroquinazolin-4(1H)-one derivative

From: Efficient synthesis of 3-alkyl-2-(-1H-1,2,3-triazolyl)methyl)thio)-2,3-dihydroquinazolin-4(1H)-one derivative via multistep synthesis approach by novel Cu@Py-Oxa@SPION catalyst


Entry	R	R′	Yield (%)
1	i-Pr	2,4-Dimethyl phenyl	81
2	i-Pr	3-Chloro phenyl	79
3	i-Pr	4-Bromo phenyl	85
4	i-Pr	4-Methyl phenyl	83
5	i-Pr	4-Nitro phenyl	80
6	i-Pr	Phenyl	82
7	Phenyl	3,5-Dimethyl phenyl	77
8	Phenyl	3-Chloro phenyl	80
9	Phenyl	4-Bromo phenyl	81
10	Phenyl	4-Nitro phenyl	84
11	Phenyl	Phenyl	86
12	Benzyl	3,5-Dimethyl phenyl	85
13	Benzyl	4-Bromo phenyl	82
14	Benzyl	4-Nitro phenyl	84
15	Benzyl	Phenyl	85
16	Benzyl	3-Chloro phenyl	78

Reaction conditions: 3-benzyl-2-(prop-2-yn-1-ylthio)quinazolin-4(3H)-one (3 mmol), N-benzyl-2-chloroacetamide (3 mmol), NaN₃ (3.6 mmol),solvent (10 mL), Cu@Py-Oxa@SPION catalyst (50 mg), r.t, 24 h

Back to article page

ISSN: 2661-801X

Contact us

Submission enquiries: bmcchemistry@biomedcentral.com
General enquiries: ORSupport@springernature.com