Table 1 Anti-proliferative activity of compounds 3a‒3L against A549, HepG2, and RKO cell lines
From: Novel phenoxy-((phenylethynyl) selanyl) propan-2-ol derivatives as potential anticancer agents
Compound | IC50 (µm) | ||
|---|---|---|---|
A549 | HepG2 | RKO | |
3a | >3000 | 882.00 ± 0.74 | 119.23 ± 0.44 |
3b | 203.10 ± 0.52 | 65.28 ± 0.24 | 71.39 ± 0.29 |
3c | 52.23 ± 0.43 | 44.94 ± 0.05 | 47.60 ± 0.19 |
3d | 87.49 ± 0.03 | >3000 | 86.73 ± 0.27 |
3e | 40.14 ± 0.87 | 23.68 ± 0.55 | 39.48 ± 0.38 |
3f | 67.85 ± 0.28 | 51.38 ± 0.22 | 40.75 ± 0.41 |
3g | 3.17 ± 0.10 | 5.10 ± 0.18 | 12.48 ± 1.43 |
3h | 0.82 ± 0.14 | 1.85 ± 0.30 | 4.20 ± 1.83 |
3i | 12.94 ± 0.13 | 23.40 ± 0.21 | 19.16 ± 0.22 |
3j | 66.00 ± 0.40 | 47.94 ± 0.44 | 46.15 ± 0.35 |
3k | 55.07 ± 0.25 | 55.96 ± 0.17 | 53.13 ± 0.53 |
3L | 110.20 ± 0.30 | 83.29 ± 0.35 | 98.73 ± 0.63 |