Table 1 Tyrosinase inhibitory activities of 6a–ja
From: Thiazolopyrimidine derivatives as novel class of small molecule tyrosinase inhibitor
| |||
|---|---|---|---|
Compound | R | IC50 (µM) | SD (µM) |
6a | H | 28.50 | 4.8 |
6b | 2-F | 40.83 | 4.3 |
6c | 3-F | 56.00 | 8.0 |
6d | 2-Cl | 34.17 | 4.9 |
6e | 4-Cl | 37.67 | 6.0 |
6f | 3-Br | 85.33 | 8.8 |
6g | 3-NO2 | 45.17 | 5.4 |
6h | 4-Me | > 250 | – |
6i | 4-OMe | 35.67 | 6.6 |
6j | 4-OH-3-OCH3 | 40.83 | 5.1 |
Kojic acidb | – | 43.50 | 5.8 |
