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Table 1 Experimental matrix and experimental plan of Box-Behnken design

From: An innovative combination of Box-Behnken design and ecofriendly approaches for the simultaneous determination of aspirin, clopidogrel, atorvastatin and rosuvastatin in their fixed-dose combination tablets

Experimental run

X1

X2

X3

pH

Organic ratio G1

(%)a

Organic ratio G2

(%)b

1

1

0

− 1

3.6

40

90

2

− 1

0

− 1

2.8

40

90

3

0

− 1

1

3.2

35

100

4

0

1

− 1

3.2

45

90

5

0

− 1

− 1

3.2

35

90

6

0

0

0

3.2

40

95

7

0

1

1

3.2

45

100

8

− 1

0

1

2.8

40

100

9

1

0

1

3.6

40

100

10

1

1

0

3.6

45

95

11

0

0

0

3.2

40

95

12

− 1

1

0

2.8

45

95

13

− 1

− 1

0

2.8

35

95

14

1

− 1

0

3.6

35

95

15

0

0

0

3.2

40

95

  1. aOrganic ratio of gradient (1)
  2. bOrganic ration of gradient (2)