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Table 2 ANOVA results of the models

From: An innovative combination of Box-Behnken design and ecofriendly approaches for the simultaneous determination of aspirin, clopidogrel, atorvastatin and rosuvastatin in their fixed-dose combination tablets

Source of variation

TP1a

T4b

p-value

p-value

Regression model

0.000

0.000

Constant

0.000

0.001

pH

0.000

0.000

Organic ratio % G1

0.309

0.002

Organic ratio % G2

0.417

0.028

(pH)2

0.000

0.000

(Organic ratio % G1)2

0.000

0.000

(Organic ratio % G2)2

0.000

0.001

(pH*Organic ratio % G1)

–

0.009

(pH*Organic ratio % G2)

–

0.004

Lack-of-Fit

0.896

0.949

  1. aTheoretical plates of peak number (1) corresponding to Aspirin
  2. bTailing factor of peak number (4) corresponding to Clopidogrel
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BMC Chemistry

ISSN: 2661-801X

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