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Table 1 The superposition of the key amino acid residues involved in type I ATP-competitive inhibitor binding in ROCK1 and ASK1 and their corresponding positional RMSD values

From: Discovery of dual rho-associated protein kinase 1 (ROCK1)/apoptosis signal–regulating kinase 1 (ASK1) inhibitors as a novel approach for non-alcoholic steatohepatitis (NASH) treatment

ROCK1 Residue

ASK1 Residue

RMSD value (Ã…)

Lys105

Lys709

1.321

Met153

Met754

1.559

Glu154

Glu755

1.576

Tyr155

Gln756

1.511

Met156

Val757

0.866

Asp216

Asp822

0.626

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BMC Chemistry

ISSN: 2661-801X

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