Discovery of dual rho-associated protein kinase 1 (ROCK1)/apoptosis signal–regulating kinase 1 (ASK1) inhibitors as a novel approach for non-alcoholic steatohepatitis (NASH) treatment

Table 13 The different criteria for hit filtration

Criterion	Cutoff value
Oprea’s lead-like filter
Molecular weight	< 450
logP	≤ 4.5
Number of hydrogen bond acceptors	≤ 8
Number of hydrogen bond donors	≤ 5
Mutagenic molecules filter	= 0
Veber’s rule
Topological polar surface area	< 140 Å²
logS	≥ − 5
PAINS Filter	No

ISSN: 2661-801X