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Fig. 5 | BMC Chemistry

Fig. 5

From: Logic-based modeling and drug repurposing for the prediction of novel therapeutic targets and combination regimens against E2F1-driven melanoma progression

Fig. 5

Radar plots: 5(A) Top screened candidate drugs for oral bioavailability based on six physicochemical properties LIPO (lipophilicity), SIZE (molecular weight), POLAR (topological polar surface area), INSOLU (insolubility), INSATU (in-saturation), and FLEX (flexibility). The pink-colored area represents the ideal range for each property i.e. XLOGP3 (− 0.7 and + 5.0), MW (150 and 500 g/mol), TPSA (20 and 130 Å2), Log S (< 6), Fraction Csp3 (< 1), and Rotatable bonds (< 9), respectively. 5(B) Prediction of water solubility, medicinal chemistry, drug-likeness, pharmacokinetic, and toxicity profile of top screened candidate drugs

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BMC Chemistry

ISSN: 2661-801X

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