Table 1 Stimulus-response and perturbation simulations. The underlined perturbed nodes have the most effect on the EMT phenotype
AR | ESR1 | FGFR1 | FLT4 | NR2F2 | NR4A1 | TGFBR1 | TGFBR2 | THRA | THRB | MDM2 | MIR25 | AKT1 | ZEB1 | CDH1 | VIM | SNAI1 | EMT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(a) Stimulus-response analysis for the initial condition. (Model simulation results of initial condition which results in higher EMT level.) | |||||||||||||||||
NaN | 1 | 1 | NaN | 1 | 1 | 1 | NaN | 0 | NaN | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 3 |
(b) Single perturbations analysis (inhibition of MDM2, MIR25 and activation of AKT1) for EMT level of 3. (Single perturbation by inhibiting MDM2 or MIR25 can bring EMT from level 3 to 1, while upregulating AKT1 resulted in EMT level to 4.) | |||||||||||||||||
NaN | 1 | 1 | NaN | 1 | 1 | 1 | NaN | 0 | NaN | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 |
NaN | 1 | 1 | NaN | 1 | 1 | 1 | NaN | 0 | NaN | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 |
NaN | 1 | 1 | NaN | 1 | 1 | 1 | NaN | 0 | NaN | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 4 |