Table 6 Comparative study of the proposed method with the previously reported methods
Parameters | Reported Method 1 [71] | Reported Method 2 [72] | Reported Method 3 [73] | Proposed Method | |||||
|---|---|---|---|---|---|---|---|---|---|
Techniques | Spectrophotometry | LC–MS/MS | Chemometric | HPLC | TLC | ||||
Drugs | TCBZ | LEVA | Mix of ten drugs | TCBZ | LEVA | TCBZ | LEVA | TCBZ | LEVA |
Linearity | 1–10 Or 2–20 mg/L | 2–14 mg/L | 0–500 µg/L (linearity rang for mix of ten drugs) | 1–9 mg/L | 5–25 mg/L | 6–60 mg/L | 3.75 -37.5 mg/L | 2–14 µg/spot | 2–14 µg/spot |
LOD | 0.08 mg/L | 0.19 mg/L | Less than 1 µg/L | ––- | ––- | 1.09 mg/L | 0.71 mg/L | 0.44 mg/L | 0.53 mg/L |
LOQ | 0.23 mg/L | 0.58 mg/L | ––– | ––- | ––- | 3.33 mg/L | 2.15 mg/L | 1.35 mg/L | 1.63 mg/L |
Application | Veterinary formulation | Milk | Veterinary formulation | Pharmaceutical dosage form | |||||