Novel analytical method based on chemometric models applied to UV–Vis spectrophotometric data for simultaneous determination of Etoricoxib and Paracetamol in presence of Paracetamol impurities

Table 2 Performance parameters of the calibration calculated for each proposed model

Parameter	PLS				ANN				MCR-ALS
Parameter	ETO	PCM	PAP	PHA	ETO	PCM	PAP	PHA	ETO	PCM	PAP	PHA
Slope^a	0.9996	0.9997	0.9991	0.9993	0.9937	1.0012	0.09961	1.0103	1	1	1	1
Intercept^a	0.0016	0.0015	0.0037	0.0028	0.03	− 0.0088	0.0054	− 0.0375	1.4787 × 10^–17	− 2.334 × 10^–16	− 2.3734 × 10^–16	0
Correlation Coefficient (r)^a	0.9996	0.9997	0.9991	0.9993	0.9995	1.00	0.9992	0.9982	0.9992	0.9996	0.9995	0.9996
RMSEC^b	0.0430	0.0458	0.0446	0.0359	0.0550	0.0178	0.0439	0.0590	0.0224	0.0403	0.0424	0.0304

^aData of the straight line plotted between predicted concentrations of each component versus actual concentrations of calibration set
^bRoot Mean Square Error of Calibration

ISSN: 2661-801X