Novel analytical method based on chemometric models applied to UV–Vis spectrophotometric data for simultaneous determination of Etoricoxib and Paracetamol in presence of Paracetamol impurities

Table 3 Prediction of validation set samples using the proposed chemometric models

Concentration (µg mL⁻¹)				PLS				ANN				MCR-ALS
Concentration (µg mL⁻¹)				Recovery %				Recovery %				Recovery %
ETO	PCM	PAP	PHA	ETO	PCM	PAP	PHA	ETO	PCM	PAP	PHA	ETO	PCM	PAP	PHA
3	10	3	5	99.76	98.83	98.92	99.18	98.59	98.02	98.81	99.12	100.68	99.47	98.77	98.91
7.5	4	5	5	101.01	99.08	99.54	98.27	99.28	100.20	99.12	98.90	98.44	100.35	99.98	99.45
3	8	5	4	99.98	100.44	100.88	98.66	98.22	98.43	100.57	99.97	100.26	99.11	98.49	99.62
6	8	4	6	100.06	98.91	99.73	100.94	99.72	98.50	98.62	100.37	100.67	99.76	98.88	100.06
4.5	10	5	6	99.25	100.18	101.45	100.39	99.50	98.83	100.56	101.60	99.22	99.90	101.30	100.02
6	10	2	2	99.99	99.76	102.62	98.48	100.90	99.44	99.04	98.45	99.86	100.70	98.14	98.83
3	6	2	3	100.82	99.11	101.81	98.56	99.67	99.43	98.69	98.30	100.33	98.77	99.65	98.92
Mean				100.12	99.49	100.71	99.21	99.41	98.98	99.34	99.53	99.92	99.72	99.32	99.40
RSD%				0.604	0.626	1.343	1.050	0.869	0.757	0.850	1.184	0.829	0.675	1.089	0.530
RMSEP^a				0.0555	0.1110	0.0540	0.0513	0.0937	0.1353	0.1080	0.0849	0.0495	0.0715	0.0420	0.0440

ISSN: 2661-801X