Novel analytical method based on chemometric models applied to UV–Vis spectrophotometric data for simultaneous determination of Etoricoxib and Paracetamol in presence of Paracetamol impurities

Table 5 Statistical comparison for the results obtained by the proposed chemometric models and the reported HPLC method for the determination of ETO and PCM in their pure powdered form

Parameter	PLS		ANN		MCR-ALS		Reported HPLC method^a
Parameter	ETO	PCM	ETO	PCM	ETO	PCM	ETO	PCM
Mean	100.21	99.49	99.13	98.98	99.92	99.42	99.98	99.89
S.D	0.605	0.626	0.746	0.749	0.828	0.645	0.992	1.102
Variance	0.366	0.391	0.556	0.562	0.685	0.416	0.984	1.214
n	7	7	7	7	7	7	9	9
Student t test^b (2.145)	0.327	0.854	1.884	1.868	0.593	0.998
F value^b (4.15)	2.688	3.098	1.768	2.164	1.435	2.919

^aHPLC method using a C₁₈ column as the stationary phase and a mixture consisting of (methanol: water) in ratio (70:30 v/v) as a mobile phase. The mobile phase was pumped at a flow rate of 1.0 mL min⁻¹. UV detection was carried out at 235.0 nm
^bThe values in parentheses are the corresponding tabulated two-tailed values at p = 0.05

ISSN: 2661-801X