Smart green spectrophotometric assay of the ternary mixture of drotaverine, caffeine and paracetamol in their pharmaceutical dosage form

Table 12 Determination of DRT, CAFF, and PAR in pharmaceutical preparations using the derivative method

Preparation	Proposed method									Comparison method [79]
	DRT			CAFF			PAR			DRT		CAFF		PAR
	Amount taken (μg/mL	Amount taken (μg/mL	% Found^b	Amount taken (μg/mL	Amount taken (μg/mL	% Found^b	Amount taken (μg/mL	Amount found (μg/mL)	% Found^b	Amount taken (μg/mL)	%Found^b	Amount taken (μg/mL)	%Found^b	Amount taken (μg/mL)	% Found^b
Petro^® tablets (40.0 mg DRT + 60 mg CAFF + 400 mg PAR)	2.00	1.974	98.70	3.00	2.974	99.13	20.00	19.867	99.34	6.00	100.65	6.00	98.97	15.00	98.93
	3.00	3.036	101.20	4.50	4.557	101.27	30.00	30.2	100.67	8.00	98.60	8.00	98.59	20.00	101.90
	4.00	3.977	99.43	6.00	5.975	99.58	40.00	39.846	99.62	10.00	100.52	10.00	101.17	30.00	100.93
‾x ± SD			99.77 ± 1.28			99.99 ± 1.13			99.87 ± 0.7
t^a			0.15			0.40			0.74
F^a			1.25			1.52			4.66

^aThe tabulated t and F values are 2.44, 6.94, respectively at P = 0.05 [81]
^bEach result was the average of three separate determination

ISSN: 2661-801X