Smart green spectrophotometric assay of the ternary mixture of drotaverine, caffeine and paracetamol in their pharmaceutical dosage form

Table 13 Determination of DRT, CAFF, and PAR in pharmaceutical preparations using the double divisor

Preparation	Proposed method									Comparison method [79]
	CAFF			DRT			PAR			DRT		CAFF		PAR
	Amount taken μg/mL	Amount found μg/mL	% Found^b	Amount taken μg/mL	Amount found μg/mL	% Found^b	Amount taken μg/mL	Amount found μg/mL	% Found^b	Amount taken μg/mL	% Found^b	Amount taken μg/mL	% Found^b	Amount taken μg/mL	% Found^b
Petro^® tablets (40.0 mg DRT + 60 mg CAFF + 400 mg PAR)	2.00	1.978	98.9	3.00	3.006	100.20	20.00	19.817	99.09	6.00	100.65	6.00	98.97	15.00	98.93
	3.00	3.044	101.47	4.50	4.472	99.38	30.00	30.362	101.21	8.00	98.60	8.00	98.59	20.00	101.90
	4.00	3.978	99.45	6.00	6.00	100.00	40.00	39.817	99.54	10.00	100.52	10.00	101.17	30.00	100.93
‾x ± SD			99.94 ± 1.35			99.46 ± 0.43			99.94 ± 1.12
t^a			0.02			0.33			0.58
F^a			1.39			10.62			1.84

^aThe tabulated t and F values are 2.44, 6.94, respectively at P = 0.05 [81]
^bEach result was the average of three separate determination

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