Smart green spectrophotometric assay of the ternary mixture of drotaverine, caffeine and paracetamol in their pharmaceutical dosage form

Table 14 Determination of DRT, CAFF and PAR in pharmaceutical preparations using the mean centering method

Preparation	Proposed method									Comparison method [79]
	DRT			CAFF			PAR			DRT		CAFF		PAR
	Amount taken (μg/mL)	Amount found (μg/mL	% Found^b	Amount taken (μg/mL	Amount found (μg/mL	% Found^b	Amount taken (μg/mL	Amount found (μg/mL)	% Found^b	Amount taken (μg/mL)	% Found^b	Amount taken (μg/mL)	% Found^b	Amount taken (μg/mL)	% Found^b
Petro^® tablets (40.0 mg DRT + 60 mg CAFF + 400 mg PAR)	2.00	2.016	100.8	3.00	3.013	100.43	20.00	20.175	100.88	6.00	100.65	6.00	98.97	15.00	98.93
	3.00	2.962	98.73	4.50	4.473	99.40	30.00	29.603	98.68	8.00	98.60	8.00	98.59	20.00	101.90
	4.00	4.022	100.55	6.00	6.013	100.22	40.00	40.213	100.53	10.00	100.52	10.00	101.17	30.00	100.93
‾x ± SD			100.03 ± 1.13			100.02 ± 0.54			100.03 ± 1.18
t^a			0.11			0.50			0.5
F^a			1.03			6.55			1.64

^aThe tabulated t and F values are 2.44, 6.94, respectively at P = 0.05 [81]
^bEach result was the average of three separate determination

ISSN: 2661-801X