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Table 7 In vitro cytotoxic activity IC50 of the ligand and its complexes

From: N′-(Furan-2-ylmethylene)-2-hydroxybenzohydrazide and its metal complexes: synthesis, spectroscopic investigations, DFT calculations and cytotoxicity profiling

Compound

In vitro cytotoxicity IC50 (µM)*

HePG-2

HCT-116

Doxorubicin

4.50 ± 0.2

5.23 ± 0.3

H2L

30.72 ± 2.2

35.40 ± 2.2

Cu(II)

82.63 ± 4.2

> 100

Co(II)

93.56 ± 4.7

89.01 ± 4.5

Ni(II)

41.47 ± 2.6

39.19 ± 2.4

Zn(II)

32.83 ± 2.3

37.27 ± 2.4

  1. *IC50 (µM): 1–10 (very strong). 11–20 (strong). 21–50 (moderate). 51–100 (weak) and above 100 (non-cytotoxic)
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BMC Chemistry

ISSN: 2661-801X

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