Table 1 Coated nanoparticles in radiosensitization studies
Study | Irradiation properties | Coating layer-nanoparticle (NP) | Finding |
|---|---|---|---|
Li et al. [57] | – | PEG-coated ceria NP | Reduced liver cell uptake over uncoated ceria |
Kong et al. [14] | 200 kVp X-rays | Glucose-coated gold NP | Increased MCF-7 cell uptake comparing to non-coated NPs |
Song et al. [56] | – | Glucose-coated gold NP | Increased HeLa and MCF-7 carcinoma cells uptake comparing to non-coated NPs |
Zhang et al. [59] | – | PEG-coated gold NP | Increased HepG2 cells uptake comparing to non-coated NPs |
Kong et al. [14] | 200 kVp X-rays | Glucose-coated gold NP | Increased cell death comparing to the non-coated NPs |
Klien et al. [131] | Low dose X-ray | Citric-coated iron oxide NP | Increased ROS generation comparing to the non-coated NPs |
Peukert al. [95] | 5 and 10Â MeV proton | PEG-coated gold NPs | Large loss of enhancement occurred for thick nanoparticle coatings |
Fathy et al. [26] | 0.5, 1, 2, 4Â Gy electron | Silica-coated iron oxide NP | Silica coating layer do not destruct the superparamagnetic behavior of iron oxide NPs |
Nakayama et al. [18] | 150 kVp | PAA-Titanium oxide NP | Increased ROS generation comparing to the non-coated NPs |
Fathy et al. [26] | 0.5, 1, 2, 4Â Gy electron | Silica-coated iron oxide NP | Increased ROS generation comparing to the non-coated NPs |
Gilles et al. [112] | X-ray | PEG-coated gold NP | Reduced ROS generation comparing to the non-coated NPs |
Singh et al. [97] | X-ray | Silica-coated iron oxide NP | Reduced ROS generation comparing to the non-coated NPs |
Zhang et al. [21] | 6Â MeV) | PEG-coated gold NPs | Clonogenic survival curve was linearly decreased in the presence of coated gold NPs and non-linear in the absence of NPs |
Chithrani et al., [125] | 6 MeV X-ray | Galactose-PEG-coated gold NP | Survival fraction decreased by an increase of radiation dose (0–8 Gy 6 MeV) in the presence of galactose-PEG-coated gold NPs was more than that of uncoated gold NPs |
Spass et al. [105] | X-ray | PEG-coated gold NP | PEG shell can substantially alter the spectra of low-energy secondary electrons escaped from the PEG-coated gold NP surface |
Belousov et al. [75] | 8Â keV to 1Â MeV X-ray | PEG-coated gold NP | Surface grafting of gold NP with PEG can change the amount and the energy spectra of secondary electrons generated within the irradiated gold core |