BMC Chemistry

Table 5 Pharmacokinetic properties for synthesized compounds (4a-4l)

From: Synthesis, design, biological evaluation, and computational analysis of some novel uracil-azole derivatives as cytotoxic agents

Entry	BBB permeation	P-gp substrate	CYP1A2 inhibitor	CYP2C19 inhibitor	CYP2C9 inhibitor	CYP2D6 inhibitor	CYP3A4 inhibitor
4a	No	No	Yes	Yes	No	No	No
4b	Yes	No	Yes	No	No	No	Yes
4c	Yes	No	Yes	No	No	No	Yes
4d	Yes	No	Yes	No	Yes	No	No
4e	Yes	No	Yes	No	No	No	Yes
4f	Yes	No	Yes	No	Yes	No	Yes
4g	Yes	No	Yes	No	Yes	No	Yes
4h	No	No	Yes	Yes	No	No	No
4i	No	No	Yes	Yes	No	No	No
4j	No	No	Yes	Yes	No	No	No
4k	No	No	Yes	Yes	No	No	No
4l	No	No	Yes	Yes	No	No	No
Erlotinib	Yes	No	Yes	Yes	Yes	Yes	Yes

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ISSN: 2661-801X

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