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Table 2 IC50 and selectivity index SI values of TPU/TiO2 and Cisplatin in MCF-7 and HepG-2 cells (24 h treatment)

From: Synthesis and biological evaluation of titanium dioxide/thiopolyurethane composite: anticancer and antibacterial effects

Cell line

IC50 values ± SD (µg/ml) after 24 h

Selective index (SI)

 = IC50 (VERO) /IC50 (Carcinogenic cell line)

MCF-7

HepG-2

Vero

MCF-7

HepG-2

TPU/TiO2

173.58 ± 6.82

122.99 ± 4.07

126.61 ± 3.89

0.729

1.029

Cisplatin

5.72 ± 0.59

3.58 ± 0.34

2.06 ± 1.58

0.360

0.575

  1. MCF-7: Breast cancer cell line. HepG-2: Hepatocellular carcinoma. Vero: Mammalian cells from African Green Monkey Kidney.Selectivity index (SI) = [IC50 (vero)/IC50 (HePG2)]. The higher the SI ratio, the theoretically more effective and safer a drug
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BMC Chemistry

ISSN: 2661-801X

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