Fig. 23From: Synthesis, anticancer evaluation, molecular docking and ADME study of novel pyrido[4ʹ,3ʹ:3,4]pyrazolo[1,5-a]pyrimidines as potential tropomyosin receptor kinase A (TrKA) inhibitorsCell cycle analysis of compounds 7b, 15b, 16a and 16c. Compounds 7b, 15b, 16a and 16c increased the ratio of cells at phases in the G2/M by about 4, 4, 2.5 and 3 times, respectively, and HepG2 cells were arrested in the cell cycle at G2/M phase by compounds 7b and 15bBack to article page