Table 1 Validation of pharmacophore model by GH score
From: Identification of new potent NLRP3 inhibitors by multi-level in-silico approaches
NO | Parameters | Model assessment |
|---|---|---|
1 | Total molecules in database (D) | 1468 |
2 | Total number of actives in database (A) | 150 |
3 | Total hits (Ht) | 8 |
4 | Active hits (Ha) | 6 |
5 | % Yield of actives[(Ha/Ht) × 100] | 75 |
6 | % Ratio of actives [(Ha/A) × 100] | 4 |
7 | Enrichment factor (E) [(Ha × D)/(Ht × A) | 7 |
8 | False negatives [A−Ha] | 144 |
9 | False positives [Ht−Ha] | 2 |
10 | Goodness of hit score (GH) | 0.76 |